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243 human ovarian cancer cell line ovcar3 atcc htb  (ATCC)


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    ATCC 243 human ovarian cancer cell line ovcar3 atcc htb
    243 Human Ovarian Cancer Cell Line Ovcar3 Atcc Htb, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1536 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/243 human ovarian cancer cell line ovcar3 atcc htb/product/ATCC
    Average 99 stars, based on 1536 article reviews
    243 human ovarian cancer cell line ovcar3 atcc htb - by Bioz Stars, 2026-03
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    human ovarian cancer cell ovcar3  (China Center for Type Culture Collection)
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    China Center for Type Culture Collection human ovarian cancer cell ovcar3
    ATG5 -knockout CAR-T cells exhibit immediate and long-lasting tumor control in vivo . NSG mice were subcutaneously implanted with 5×10 6 <t>OVCAR3</t> tumor cells on the left flank. ATG5 -integrated (n=8) or AAVS1 -integrated (n=7) were intravenously administered 46 days after tumor implantation. Tumors were measured twice per week using digital calipers, and mice were euthanized upon reaching humane endpoint (tumor area greater than 160mm 2 ) or at termination of study (125 days after CAR-T infusion). (A) Growth curve showing tumor area over time following treatment with 4×10 6 ATG5 -integrated (red) or AAVS1 -integrated (black) CAR-T cells (one line = one mouse). (B-C) Scatter plots showing average tumor area for the first 17 days of the experiment shown in (A). Solid lines indicate the line of best fit for each group. Error bars represent +/-SEM. (D) Kaplan-Meier survival curve for the experiment shown in (A). Significance was determined by log-rank test: *p < 0.05.
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    ATG5 -knockout CAR-T cells exhibit immediate and long-lasting tumor control in vivo . NSG mice were subcutaneously implanted with 5×10 6 OVCAR3 tumor cells on the left flank. ATG5 -integrated (n=8) or AAVS1 -integrated (n=7) were intravenously administered 46 days after tumor implantation. Tumors were measured twice per week using digital calipers, and mice were euthanized upon reaching humane endpoint (tumor area greater than 160mm 2 ) or at termination of study (125 days after CAR-T infusion). (A) Growth curve showing tumor area over time following treatment with 4×10 6 ATG5 -integrated (red) or AAVS1 -integrated (black) CAR-T cells (one line = one mouse). (B-C) Scatter plots showing average tumor area for the first 17 days of the experiment shown in (A). Solid lines indicate the line of best fit for each group. Error bars represent +/-SEM. (D) Kaplan-Meier survival curve for the experiment shown in (A). Significance was determined by log-rank test: *p < 0.05.

    Journal: bioRxiv

    Article Title: Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors

    doi: 10.1101/2025.10.09.681473

    Figure Lengend Snippet: ATG5 -knockout CAR-T cells exhibit immediate and long-lasting tumor control in vivo . NSG mice were subcutaneously implanted with 5×10 6 OVCAR3 tumor cells on the left flank. ATG5 -integrated (n=8) or AAVS1 -integrated (n=7) were intravenously administered 46 days after tumor implantation. Tumors were measured twice per week using digital calipers, and mice were euthanized upon reaching humane endpoint (tumor area greater than 160mm 2 ) or at termination of study (125 days after CAR-T infusion). (A) Growth curve showing tumor area over time following treatment with 4×10 6 ATG5 -integrated (red) or AAVS1 -integrated (black) CAR-T cells (one line = one mouse). (B-C) Scatter plots showing average tumor area for the first 17 days of the experiment shown in (A). Solid lines indicate the line of best fit for each group. Error bars represent +/-SEM. (D) Kaplan-Meier survival curve for the experiment shown in (A). Significance was determined by log-rank test: *p < 0.05.

    Article Snippet: OVCAR3 human ovarian cancer cells (HTB-161, ATCC) were grown in ATCC-formulated RPMI 1640 (Gibco) supplemented with 20% FBS, 0.01 mg/mL bovine insulin (Sigma), and 1% penicillin-streptomycin.

    Techniques: Knock-Out, Control, In Vivo, Tumor Implantation